Amino Acids and Peptides. X. Synthesis of Two Dotriacontapeptides Corresponding to C-terminal Sequence 30–61 (fragment Α) of Human Liver Metallothionein II and Their Heavy Metal Binding Properties

Two kinds of dotriacontapeptides corresponding to C-terminal sequence 30–61 of human liver metallothionein, both containing 11 cysteine residues, were synthesized by the conventional fragment condensation method employing the HF deprotection or MSA deprotection method at the final step. Their heavy metal (Zn, Cd, or Cu) binding activity was examined, and it was found that their heavy metal binding properties were quite similar to those of native human liver thionein.