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(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Lain-Yen Hu,Daniel Du,Jennifer Hoffman,Yvonne Smith,Victor Fedij,Catherine R Kostlan,Theodore R Johnson,Yun Huang,Steve Kesten,William Glen Harter,Wen Song Yue,Jie Jack Li,Nicole C Barvian,Lorna H Mitchell,Huangshu John Lei,Bruce A Lefker,Mathew Carroll,Danielle Dettling,Teresa Krieger-Burke,Brian Samas,Radhika Yalamanchili,Kimberly Lapham,David Pocalyko,Drago R Sliskovic,Susan Ciotti,Brenda Stoller,Mostofa A Hena,Qizhu Ding,Samarendra N Maiti,Michael A Stier,Howard Welgus

Bioorganic & Medicinal Chemistry Letters（2007）

Cited 15|Views63
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Abstract
The synthesis, pharmacology, and pharmacokinetic profiles of (1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This agent demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.
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Key words
Aryl-ether,Hair growth,Sebum reduction
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