Effect of Baidanhuang Nasal Irrigation Solution on Recovery of Nasal Mucosal Function and Morphology in Chronic Rhinosinusitis Patients After Surgery

Objective To observe the therapeutic effect of Baidanhuang nasal irrigation solution(BNIS)on the recovery of nasal mucosal function and morphology in chronic rhinosinusitis patients after surgery at different time points.Methods A total of 92 chronic rhinosinusitis patients were enrolled and were randomly divided into groups A,B and C.Group A(N=32) was given nasal irrigation of BNIS,group B(N=31)was given nasal irrigation of Dexamethasone and Gentamicin solution,and group C(N=29)had no nasal irrigation.At five time points of before surgery,and 6 weeks,3 months,6 months and one year after surgery,nasal endoscopic sign was scored and mucociliary transport rate(MTR) was measured,and their therapeutic effect was also evaluated Results The total effective rate and cure rate had no significant difference(P0.05) among the three groups.The nasal cleaning time for group A and group B was shorter than that for group C(P0.05 or P0.01),and the time for group A was the shortest(P0.01).The difference of epithelization time was insignificant among the three groups(P0.05).Six weeks after surgery,the total nasal endoscopic scores had significant difference among the three groups(P0.05),the scores of mucosal edema in group A were superior to those in group B and group C(P0.01),and MTR in group A and group B was higher than that in group C(P0.01),MTR in group A being the highest(P0.01).Three months after surgery,the differencesof total nasal endoscopic scores were insignificant among the three groups(P0.05),the scores of mucosal edema in group A were superior to those in group B and group C(P0.01),and MTR in groups A and B was higher than that in group C(P0.01),MTR in group A being the highest(P0.01).Six months and one year after surgery,three groups showed no significant differences of nasal endoscopic sign and MTR(P0.05).Conclusion After surgery,the recovery of nasal mucosal function and morphology is not at the same pace.Baidanhuang nasal irrigation solution shows an effect on improving the recovery of nasal mucosa of chronic rhinosinusitis patients,especially in the early stage after surgery.