A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.

D Guay,J Y Gauthier,C Dufresne,T R Jones,M McAuliffe,C McFarlane,K M Metters,P Prasit,C Rochette,P Roy,N Sawyer,R Zamboni

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1998）

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摘要

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair(R)) is described. This work has led to the identification of a number of potent and orally active cysLT(1), receptor (LTD4 receptor) antagonists including 2ab (1,-733,321) as an optimized candidate. (C) 1998 Elsevier Science Ltd. All rights reserved.

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关键词

receptor antagonists,pyridyl analogs,non-quinoline

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