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不同浓度甲醛致小鼠肾细胞DNA损伤效应研究

XU Qian,YANG Xu,YANG Guangtao,HE Hujun,PENG Guangyin,DING Shumao

Acta Scientiae Circumstantiae（2007）

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Abstract
为了探讨甲醛导致生物机体内的DNA损伤效应及其剂量-效应关系,通过不同浓度的液态甲醛对小鼠肾细胞进行染毒,并分别运用了单细胞凝胶电泳实验、荧光检测法实验和KCl-SDS沉淀法实验进行研究.结果显示,甲醛在低浓度(5μmo·lL-1)时,具有致DNA断裂的作用;在中等浓度(25μmo·lL-1)时,对DNA的损伤作用以DNA-DNA交联为主;在高浓度(125、625μmo·lL-1)时,对DNA的损伤作用以DNA-蛋白质交联为主.
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Key words
DNA-DNA crosslinks,DNA breakage,DNA-protein crosslinks,kidney cells,formaldehyde
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