Juvenile Myelomonocytic Leukemia Relapsing After Allogeneic Bone Marrow Transplantation Successfully Treated With Interferon-Alpha
Bone marrow transplantation(2000)
摘要
We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) which relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-alpha (IFN-alpha). One year after starting the therapy, he remains clinically well and in complete remission while continuing treatment with IFN-alpha and bestatin, Although the precise mechanism by which remission was induced is uncertain, a GVL effect combined with a direct antileukemia effect of IFN-alpha may be responsible. Further assessment of the role of IFN-alpha in relapsed JMML patients is warranted.
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关键词
juvenile myelomonocytic leukemia,interferon alpha,bestatin,bone marrow transplantation,relapse
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