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宫颈癌发病机制的研究进展

Xiao-jin ZHANG,Sui-qi GUI

Chinese Journal of Woman and Child Health Research（2008）

Cited 27|Views6
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Abstract
宫颈癌是发生在全球妇女中仅次于乳腺癌的第2个常见的恶性肿瘤.人乳头状瘤样病毒感染是宫颈癌发生最主要的危险因素.宫颈癌发生的中心环节是人乳头状瘤样病毒E6、E7蛋白与细胞癌基因和抑癌基因相互作用导致相关癌基因激活、抑癌基因失活、端粒酶活性高表达和机体免疫调节机制失衡等一系列病理改变引起细胞永生化而癌变.
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Key words
telomerase,human papillomavirus(HPV),anti-oncogene,oncogene,cervical carcinoma
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