Synthetic HDL as a new treatment for atherosclerosis regression: has the time come?
Nutrition, Metabolism and Cardiovascular Diseases(2008)
Abstract
Plasma high-density lipoprotein cholesterol (HDL-C) has received considerable attention as a potential therapeutic target to further reduce cardiovascular events in the statin era. One therapeutic approach to enhance HDL-mediated atheroprotection involves the use of small, synthetic and orally-active compounds that substantially raise plasma HDL-C levels.
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Key words
HDL,sHDL,Atherosclerosis,Torcetrapib,Plaque stabilization/regression
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