高危型人类乳头瘤病毒检测对不典型鳞状细胞分流监测的临床价值
Chinese Journal of Obstetrics & Gynecology and Pediatrics(2006)
Abstract
目的评价高危型人类乳头瘤病毒(HPV)检测对不典型鳞状上皮细胞(atypical squamous cells of undetermined significance,ASCUS)分流监测的临床价值。方法对654例宫颈细胞学检查结果为ASCUS的患者,进行高危型HPV检测和阴道镜检查,镜下定位活检可疑病灶,以病理学诊断作为金标准。结果 654例中,高危型HPV检测呈阳性的病例为411例,阳性率为62.8%。经病理学确诊宫颈上皮内瘤样病变(CIN)病例为58例,占总数的8.9%(58/654),其中CINⅡ和CINⅢ共计43例,占CIN的 74.1%(43/58);CINⅡ,CINⅢ的高危型HPV阳性率分别为80.8%及94.1%。ASCUS患者中以高危型 HPV检测、直接选择阴道镜检查,检出CIN的敏感度分别为88.9%和65.5%;对诊断CINⅡ和CINⅢ,高危型HPV的敏感度为94.1%,阴道镜的敏感度为65.1%。结论 ASCUS患者中高危型HPV的CINⅡ和 CINⅢ检出有较高的敏感度,对ASCUS可有效地进行分流监测,患者可不必再做阴道镜检查和活检。
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Key words
cervical intraepithelial neoplasia (CIN),atypical squamous cell of undetermined significance (ASCUS),diagnosis,colposcopy,high-risk HPV test
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