Total regression of extensive conjunctival intraepithelial neoplasia with superficial corneal invasion treated with topical mitomycin C 0.02%.

To report complete resolution of extensive conjunctival intraepithelial neoplasia in a patient treated with topical mitomycin C.Based on clinical examination, impression cytology was performed on the corneal-conjunctival lesion. Management consisted of topical mitomycin 0.02%, administered four times a day for four 1-week cycles, with 1 week off between cycles.Complete resolution of the neoplasm was observed by slit lamp examination at 5 weeks of treatment, and histological resolution by 7 weeks of treatment. There were no complications due to the use of mitomycin.Topical mitomycin C 2 mg/ml (0.02%) may be a safe and effective treatment for conjunctival intraepithelial neoplasm prior to surgical removal.