Comparison of the efficacies of cutaneous and subcutaneous administration of tactivin for correction of secondary immunodeficiency in infants and young children
Bulletin of Experimental Biology and Medicine(1994)
Abstract
A method for noninvasive administration of immunomodulators, specifically, of tactivin, has been developed. The dosage form
for cutaneous applications represents a special film containing the immunocorrector tactivin. Before application the film
and underlying skin site are moistened with normal saline, after which the film is held with a plaster on the skin of the
forearm flexor surface for 10–12 h. The optimal dose of tactivin for applications is 100μg. Comparative analysis showed that
the efficacies of cutaneous and subcutaneous administration of tactivin to infants and young children are comparable according
to immunological criteria and clinical results.
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Key words
cutaneous therapeutic systems,immunocorrection,tactivin
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