Comparison of the efficacies of cutaneous and subcutaneous administration of tactivin for correction of secondary immunodeficiency in infants and young children

A method for noninvasive administration of immunomodulators, specifically, of tactivin, has been developed. The dosage form for cutaneous applications represents a special film containing the immunocorrector tactivin. Before application the film and underlying skin site are moistened with normal saline, after which the film is held with a plaster on the skin of the forearm flexor surface for 10–12 h. The optimal dose of tactivin for applications is 100μg. Comparative analysis showed that the efficacies of cutaneous and subcutaneous administration of tactivin to infants and young children are comparable according to immunological criteria and clinical results.