DNA binding activity and inhibition of DNA-protein interactions

Claudio Nastruzzi,Enea Menegatti,Costanza Pastesini,Rita Cortesi,Elisabetta Esposito,Marcello Spano,Roberto Biagini,Eugenia Cordelli,Giordana Feriotto,Roberto Gambari

BIOCHEMICAL PHARMACOLOGY（1992）

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摘要

In the present study are reported the differential DNA binding activity of the anti-tumor polyamidine tetra-p-amidinophenoxyneopentane (TAPP-H) and its 2'-halo derivative (TAPP-Br), and their effects on the binding of the recombinant Epstein-Barr virus (EBV) nuclear antigen to a synthetic oligonucleotide mimicking the target DNA sequence present in the EBV genome. In addition, the proliferation kinetics and cell cycle analysis of human leukemia K562 cells treated with TAPP-H and TAPP-Br are reported. The possible in vivo relationship between DNA binding affinity and cytotoxicity is also discussed.

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关键词

tetra- p -amidinophenoxy-neopentane,salmon sperm DNA,Epstein-Barr virus nuclear antigen 1,EBNA-1-mer,ssDNA,double-stranded synthetic oligonucleotide containing the recognition site of EBNA-1,EBNA-1,EBV,TAPP-H,Epstein-Barr virus,double-stranded synthetic oligonucleotide containing the recognition site of Oct-1,mer,oligomer,TAPP-Br,2'-bromo derivative of tetra- p -amidinophenoxyneopentane,octamer binding protein 1,Oct-1-mer,Oct-1

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