Effects of ethinyl estradiol and ibuprofen compared to placebo on endometrial bleeding, cervical mucus and the postcoital test in levonorgestrel subcutaneous implant users
Contraception(2008)
Abstract
BACKGROUND:The study was conducted to evaluate ethinyl estradiol (EE) or ibuprofen (IBU) compared to placebo (PL) on spotting and bleeding (S/B) and a postcoital test (PCT) in women using the levonorgestrel subcutaneous implant. Women experiencing excessive S/B were enrolled in a multicenter prospective randomized study using EE, IBU or PL.
OUTCOME MEASURES:Duration of S/B and a PCT were evaluated. Statistical analysis used a general linear model procedure with Duncan's multiple range tests for individual variables.
RESULTS:One hundred seven women were evaluated, and there was no difference in the duration of bleeding among the three therapies, while the mean number of spotting days were 1.8 for EE and 2.8 for PL (p=.04). There was no effect of IBU on S/B. No effect on cervical mucus or sperm was found between treatments.
CONCLUSION:There was a decrease in spotting but no effect on bleeding with EE compared to PL.
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Key words
Levonorgestrel implants,Endometrium,Bleeding,Ethinyl estradiol,Ibuprofen,Postcoital test,Prospective,Double dummy,Randomized clinical trial
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