The Yield of Peripheral Blood (PB) Graft and the Changes of Adhesion Molecules Expression on PB CD34 Positive Cells Before and During Administration of Granulocyte-Colony Stimulating Factor (G-CSF)

Around 10 % and 1.7% of healthy related PB donors in Japan responded poorly to G-CSF, from whom CD34+ cells below 2x10E6 /kg and 1x10E6 /kg (donor's body weight: dBW) harvested respectively. From October 2010, Japan Marrow Donor Program started transplantation using unrelated donor's PB graft. Poor mobilization of PB graft is disadvantageous for both the donor and the patient to whom transplanted by the PB graft. Therefore it is useful to predict the total yield of PB graft before or soon after G-CSF administration.