Immunological substance testing on human lymphatic micro-organoids in vitro.
Journal of Biotechnology(2010)
摘要
Pharmaceutical drugs and compounds used for consumer products may bear the risk of unexpected immuno-toxicological side effects, such as sensitization, allergy, anaphylaxis or immunogenicity. Modern biopharmaceuticals with high potency and target specificity, like antibodies and cytokines need to be tested for their therapeutical doses, their exposition regimens and their immune functionality prior to first-in-man applications.
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关键词
Lymph node model,In vitro testing,Culture system,Bioreactor,Immunogenicity,Immunotoxicity
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