Study on biological characteristics of type 2 diabetic KK-Ay/Ta mice.
Journal of Shanghai Jiaotong University(Agricultural Science)(2009)
Abstract
To compare the biological characteristics of KK-Ay/Ta mice in growth curve,glucose metabolism,serum insulin,weight of major organs,and organ coefficient with C57BL/6JSlac mice as the control group,then explore the morphologic changes of kidney,liv-er and pancreas.The result showed: 1.The weight,glucose and serum insulin in KK-Ay/Ta mice were higher than the control group at the same age(P0.01).2.The heart and pancreas showed significant difference(P0.05).Between KK-Ay/Ta and C57BL/6JSlac male mice,the liver,spleen,kidney,fat showed high significant difference(P0.01).And there were high significant difference in every or-gan and fat weight of female mice.3.The glomerulus hyaline degeneration,capillary basement membrane incrassation and hyaline cast in renal tubules were also observed in KK-Ay/Ta.The liver appeared significant adipose degeneration,cell putrescence,inflam-matory cell infiltration and fibroplastic proliferation.At the same time,the number of glomeruli pancreatici and islet cells decreased obviously.The results shows that the KK-Ay/Ta mice exhibits hyperglycemia,high insulin resistance,insufficiency of islet function,renal and hepatic alterations,which makes it with obesity as a suitable disease model for studying type 2 diabetes mellitus.
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Key words
type 2 diabetic,serum insulin,blood glucose,kk-ay/ta mice,tissue injury,body weight,diabetes mellitus,obesity,adipose tissue,insulin,renal function,carbohydrate metabolism,heart
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