Study on biological characteristics of type 2 diabetic KK-Ay/Ta mice.

To compare the biological characteristics of KK-Ay/Ta mice in growth curve,glucose metabolism,serum insulin,weight of major organs,and organ coefficient with C57BL/6JSlac mice as the control group,then explore the morphologic changes of kidney,liv-er and pancreas.The result showed: 1.The weight,glucose and serum insulin in KK-Ay/Ta mice were higher than the control group at the same age(P0.01).2.The heart and pancreas showed significant difference(P0.05).Between KK-Ay/Ta and C57BL/6JSlac male mice,the liver,spleen,kidney,fat showed high significant difference(P0.01).And there were high significant difference in every or-gan and fat weight of female mice.3.The glomerulus hyaline degeneration,capillary basement membrane incrassation and hyaline cast in renal tubules were also observed in KK-Ay/Ta.The liver appeared significant adipose degeneration,cell putrescence,inflam-matory cell infiltration and fibroplastic proliferation.At the same time,the number of glomeruli pancreatici and islet cells decreased obviously.The results shows that the KK-Ay/Ta mice exhibits hyperglycemia,high insulin resistance,insufficiency of islet function,renal and hepatic alterations,which makes it with obesity as a suitable disease model for studying type 2 diabetes mellitus.