A new photolabile carboxyl protecting group for native chemical ligation

Native chemical ligation (NCL) at Glu–Cys sites requires carboxyl protection that is compatible with the chemistry used for assembling the peptides. In the case of Fmoc-chemistry our novel BCMACM-group is particularly suitable for NCL because of the good solubility in aqueous solvent systems and mild conditions of photolytic removal.