银杏叶对小鼠抗炎镇痛作用的研究
Journal of Traditional Chinese Veterinary Medicine(2008)
Abstract
目的:观察不同剂量银杏叶水煎醇沉液对小鼠的抗炎、镇痛作用.方法:采用二甲苯诱导小鼠耳壳肿胀法,50只小鼠随机均分5组,分别为银杏叶水煎醇沉液腹腔注射高(10.0 g/kg)、中(5.0 g/kg)、低(2.5 g/kg)剂量组,空白对照组腹腔注射等量生理盐水,阳性对照组腹腔注射地塞米松(10 ms/kg),连续给药6 d,测定小鼠耳廓的肿胀率和肿胀抑制率;采用热板法测定小鼠的镇痛作用,取合格小鼠100只随机均分10组,分别为银杏叶水煎醇沉液腹腔注射和水煎液灌胃高(10.0 g/kg)、中(5.0 g/kg)、低(2.5 g/kg)剂量组,空白对照组腹腔注射和灌胃等量生理盐水,阳性对照组腹腔注射和灌胃安乃近(20 ms/kg),给药后30 min测定小鼠的痛闯值的变化.结果:腹腔注射银杏叶水煎醇沉液各剂量组小鼠耳廓肿胀率均低于生理盐水组(P<0.01), 其肿胀抑制率以高剂量组最高;与生理盐水组比较,腹腔注射银杏叶水煎醇沉液各个剂量组痛阚值均明显提高(P<0.01);灌胃给药高剂量组有镇痛作用(P<0.01).结论:银杏叶水煎醇沉液腹腔注射对小鼠具有较强的抗炎和镇痛作用,灌胃给药镇痛效果相对较差.
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Key words
anti-inflammatory effect,analgesic effect,extract by water and alcohol,Ginkgo biloba L.leaf,water decoction
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