Integrated micro potentiometric immunosensor for percent hemoglobin-A1C based on nano-gold multilayer
NEMS（2010）
Abstract
We present a novel method for antibodies immobilization to fabricate a percent hemoglobin-A1c micro immunosensor. Nano-gold which is introduced by a novel seed mediated growth method is used for a micro potentiometric immunosensor of hemoglobin-A1c (HbA1c). To eliminate the nonspecific sites, nano-gold is capped with mixed self-assembled monolayers (MSAMs) to immobilize the antibodies stably and efficiently. This biomimetic layer preparation method has been applied firstly for modifying micro extended gate electrode array of biologically sensitive field-effect-transistor (BioFET). And combining with standard CMOS and MEMS techniques, this immunosensor exhibited high sensitivity, good stability, and achieved multichannels detection.
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Key words
mems technique,biosensors,gold,hemoglobin-a1c,mixed self-assembled monolayers,biomimetic layer preparation,nanobiotechnology,micropotentiometric immunosensor,antibodies immobilization,micro extended gate electrode array,micro immunosensor,potentiometric,organic compounds,ion-sensitive field-effect transistors (isfets),self-assembly,gold nanoparticles,biofet,nanogold multilayer,field effect transistors,cmos technique,biologically sensitive field effect transistor,self assembled monolayer,logic gates,electrodes,immune system,field effect transistor,self assembly
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