火把花根片对实验性自身免疫性脑脊髓炎大鼠脑IL-2和IFN-γ mRNA的影响
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences(2012)
Abstract
目的:探讨火把花根片对实验性自身免疫性脑脊髓炎(EAE)Wistar大鼠的治疗作用及IL-2和IFN-γmRNA的影响。方法:模型组采用豚鼠髓鞘蛋白匀浆和福氏完全佐剂诱发大鼠急性EAE;治疗组在模型组基础上予以火把花根片(300 mg.kg-1,BID)治疗,观察症状并评分;HE染色和Loyez氏髓鞘染色,观察病理和髓鞘改变;RT-PCR法测定脑组织的IL-2和IFN-γ的mRNA表达水平。结果:治疗组未出现EAE症状,脑组织IL-2和IFN-γ的mRNA表达水平分别为0.345±0.032、0.353±0.023,与模型组比较P<0.01;脑和脊髓小血管周围炎症细胞浸润明显减少;髓鞘结构完整。结论:火把花根片对EAE有治疗作用,其机制与抑制了脑组织IL-2和IFR-γ的mRNA表达有关。
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Key words
autoimmune,encephalomyelitis,interleukin-2,experimental/drug ther,interferon-γ,colquhoumai root tablet
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