Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes.

E Maronde,H W Korf,P Niemann,H G Genieser

JOURNAL OF PINEAL RESEARCH（2001）

Cited 5|Views9

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Abstract

A modified analog of cyclic adenosine 3',5'-monophosphate (cAMP), Sp-adenosine-3',5'-monophosphorothioate, designed to be highly membrane-permeable and resistant towards phosphodiesterases was found to induce the phosphorylation of the cAMP-regulated transcription factor cyclic AMP-responsive element binding protein in cultured rat pinealocytes more efficiently than previously described cAMP analogs.

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Key words

cAMP analogs,CREB phosphorylation,membrane permeability,PDE resistance,rat pinealocytes

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