Optimization of a screening lead for factor VIIa/TF

Wendy B Young,Aleksandr Kolesnikov,Roopa Rai,Paul A Sprengeler,Ellen M Leahy,William D Shrader,Joan Sangalang,Jana Burgess-Henry,Jeff Spencer,Kyle Elrod,Lynne Cregar

Bioorganic & Medicinal Chemistry Letters（2001）

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摘要

The structure-based design and progression of a screening lead to a 3nM factor VIIa/TF inhibitor with improved selectivity versus related enzymes is described.

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enzyme

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