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丙泊酚复合氯诺昔康预防全麻拔管期心血管反应的临床观察

The Journal of Clinical Anesthesiology(2009)

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Abstract
目的观察丙泊酚复合氯诺昔康对腹腔镜下胆囊切除术(LC)患者气管拔管时心血管反应的预防作用。方法LC患者40例随机均分为观察组(T组)和对照组(C组)。T组于气管拔管前给予静注丙泊酚0.5~1.0mg/kg和氯诺昔康8mg,2~3min后予吸痰拔管;C组不用药。观察围拔管期BP、RR、HR、SpO2、拔管时间、清醒时间、躁动发生情况及有无恶心、呕吐等不良反应。结果T组拔管时BP、RR、HR平稳,明显优于C组,躁动发生例数也少于C组(P<0.05或P<0.01);两组间拔管时间、清醒时间差异无统计学意义。结论LC患者在拔除气管导管前给予丙泊酚复合氯诺昔康能有效预防气管拔管时的心血管反应,且不良反应少。
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Key words
Adverse cardiovascular response,Lornoxiam,Propofol,Extubation
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