OC123: Significance of CRL discrepancy at 11-14 weeks in twin pregnancies

Objectives: Polycystic ovary syndrome (PCOS) is a condition marked by chronic anovulation, hyperandrogenaemia and infertility and affects approximately 5–10% of women of reproductive age. It is kown that relative hyperestrogenism and anovulation are involved in the etiology of benign breast disease, since mammary gland growth is influenced by a critical balance between estrogens and progesteron action. The aim of this study was to evaluate the association between a polycystic ovary syndrome and fibrocystic breast disease. Methods: In this case-control study 93 women aged between 17–36 years, not using oral contraceptives were entered into the sudy. Laboratory, clinical and ultrasound findings were used to diagnose a polycystic ovary syndrome. The study group was consisted of 53 PCOS women and the control group was consisted of 40 women. All patients were performed breast ultrasonography. Fibrocystic breast disease is described as common benign changes involving the tissues of the breast. Results: Mean ages were similar in both groups. Twenty one (39.6%) of 53 women with a PCOS had fibrocystic breast disease. Five (8%) of 40 controls had fibrocystic breast disease. The difference between the groups was statistically significant (P < 0.05). One lipoma, 2 fibroadenoma were determined in a polycystic ovary syndrome group. Controls had one lipoma and 3 fibroadenoma. Conclusions: This study showed a statistically significant association between a polycystic ovary syndrome and fibrocystic breast disease. Women with a polycystic ovary syndrome should be evaluated for fibrocystic breast disease.