Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor
FEBS Letters(1997)
摘要
The main objective of this work was to unequivocally determine the C-terminal sequence of human milk free secretory component (SC). It was found to end at arginine-585, i.e. 33 amino acids downstream from the major heterogeneous C-terminal residue previously identified for colostrum SC. In contrast, our data showed that the C-terminal end of SC was found to be homogeneous. Conflicting assignments, Asp/Gln, a missing Asn-211, Asp/Asn, Glu/Gln were corrected and found to agree with the cDNA sequence. An Ala/Val substitution at position 562 (domain VI) was identified. Its genetic significance is uncertain at present.
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关键词
Secretory component,Amino acid sequence,Polymeric immunoglobulin receptor,Carboxy-terminal region
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