2-Trifluoroacetyl aminoindoles as useful intermediates for the preparation of 2-acylamino indoles

Tetrahedron Letters(2011)

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Abstract
A three-step method was developed to convert N-1 unprotected 3-substituted indoles to 3-substituted 2-acylaminoindoles. Established indole chlorination chemistry was employed to generate stable 2-trifluoroacetylamino indoles, which were subsequently deprotected and selectively acylated.
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Key words
2-Aminoindole,Acylaminoindole,Chloroindolenine,2-Aminoindole acylation
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