Transformation of compounds containing C-N bonds on heterogeneous catalysis

The transformations of the condensed-skeleton β-lactams (azetidin-2-ones) 1 – 4 were studied under various reductive conditions. On the action of a complex metal hydride, selective formation of azetidines occurs. A new heterogeneous catalytic method is reported, which is suitable for the preparation of cyclic 1,3-aminoalcohols in the presence of Raney Ni in liquid-phase hydrogénation. On a Ni on Cab-O-Sil® catalyst in a flow reactor, 1 is converted to the carboxylic acid amide 9 with high selectivity.