Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the κ opioid receptor
Bioorganic & Medicinal Chemistry Letters(2008)
摘要
A series of 2-substituted sulfamoyl arylacetamides of general structure 2 were prepared as potent κ opioid receptor agonists for the dynorphin A binding domain.
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关键词
κ Opioid receptor agonists,Dynorphin A,Chimeric receptors
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