Identification of a potent and selective 5-HT1B receptor antagonist

Paul A. Wyman,Howard R. Marshall,Sean T. Flynn,Ron J. King,Mervyn Thompson,Paul W. Smith,Michael S. Hadley,Gary W. Price,Claire M. Scott,Lee A. Dawson

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Introduction of cis-2,6-dimethyl substitution onto the piperazine ring of a mixed 5-HT1ABD receptor antagonist offers a combination of both excellent selectivity over 5-HT1A and 5-HT1D receptors and low intrinsic activity.

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关键词

5-HT1B receptor antagonist,SB-616234

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