Constituents Of Tropical Medicinal Plants. Part 87 - Rosane Diterpenes And Bis-Dinorditerpenes From Hugonia Casteneifolia

From the root bark of Hugonia casteneifolia three new rosane-type diterpenes, hugorosenone (3 beta-hydroxy-1(10),15-rosadien-2-one), 18-hydroxyhugorosenone (3 beta, 18-dihydroxy-1(10),15-rosadien-2-one), hugo-rosediol (3 beta,18-dihydroxy-1(10), 15-rosadiene), and the two bis-dinorditerpenes, hugonone A and hugonone B, have been isolated. Structural determination was achieved by spectroscopic methods. Extracts of the root bark exhibited cytotoxic activity in the brine shrimp bioassay, and hugorosenone was demonstrated to be the corresponding active principle. (C) 1998 Elsevier Science Ltd. All rights reserved.