Study on the Formulation Optimization and Preparation Technology of Pioglitazone Hydrocloride Sustained-release Tablets

OBJECTIVE:To screen the formulation of Pioglitazone hydrocloride sustained-release tablets,and to optimize the preparation technology of it.METHODS:The type,amount and preparation technology of matrix material,bulking agent,and adhesive were investigated by determining accumulative rate of pioglitazone at different time in PBS to determine the formulation and preparation technology of tablet core.RESULTS:The tablet core was prepared with HPMC(K15M) as matrix material,microcrystaline celulose as the bulking agent and 70% ethanol solution of 2% HPMC(E5) as adhesive material for Pioglitazone hydrocloride sustained-release tablets.The tablet was prepared by film coating method using 70% ethanol solution of Opadry as film coating material.Accumulative drug release rate of prepared 3 batches of samples were all more than 90% in 12 h.CONCLUSION:The preparation method is simple and the tablet is up to the requirements of sustained-release preparation.