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Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Mark D. Wittman,Balu Balasubramanian,Karen Stoffan,Upender Velaparthi,Pieying Liu,Subramaniam Krishnanathan,Joan Carboni,Aixin Li,Ann Greer,Ricardo Attar,Marco Gottardis,Chiehying Chang,Bruce Jacobson,Yax Sun,Steven Hansel,Mary Zoeckler,Dolatrai M. Vyas

Bioorganic & Medicinal Chemistry Letters（2007）

引用 30|浏览30
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摘要
A novel class of benzimidazole–pyridone inhibitors of insulin-like growth factor I (IGF-1R) kinase is described.
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关键词
Insulin-like growth factor,IGF-1R,Inhibitor,Kinase,ATP competitive,Benzimidazole,4-Aminopyridone,Substituted 2-hydroxy-2-phenyl-aminoethanol
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