Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives
Bioorganic & Medicinal Chemistry Letters(2007)
摘要
Quaternized promazine derivatives 4b (R1=CF3, R2=4-Cl; X=Cl) and 4c (R1=CF3; R2=3-Cl; X=Cl) inhibit actively growing and non-replicating Mycobacterium tuberculosis at <4 and <8μM, respectively.
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关键词
Antitubercular,Promazine,Promethazine,Chlorpromazine,Triflupromazine,Quaternized
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