Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives

Aaron B. Bate,Jay H. Kalin,Eric M. Fooksman,Erica L. Amorose,Cristofer M. Price,Heather M. Williams,Michael J. Rodig,Miguel O. Mitchell,Sang Hyun Cho,Yuehong Wang,Scott G. Franzblau

Bioorganic & Medicinal Chemistry Letters（2007）

引用 44|浏览27

暂无评分

摘要

Quaternized promazine derivatives 4b (R1=CF3, R2=4-Cl; X=Cl) and 4c (R1=CF3; R2=3-Cl; X=Cl) inhibit actively growing and non-replicating Mycobacterium tuberculosis at <4 and <8μM, respectively.

查看译文

关键词

Antitubercular,Promazine,Promethazine,Chlorpromazine,Triflupromazine,Quaternized

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要