Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities.

Tomoaki Miura,Satomi Natsume,Kenichi Kanemoto,Eiki Shitara,Hideki Fushimi,Takuji Yoshida,Keiichi Ajito

Bioorganic & Medicinal Chemistry（2010）

Cited 20|Views11
No score
Abstract
The design and synthesis of 16-membered azalides modified at the C-15 and 4″ positions are described. 3-Hydroxyl azalides having an arylpropenyl and an ethylcarbamoyl group at the C-15 and C-4″ position, respectively, exhibited significant improvement in antibacterial activities against erm-resistant Streptococcus pneumoniae.
More
Translated text
Key words
16-Membered macrolide,Azalide,Acyl migration,S. pneumoniae,Antibacterial activity
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined