Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4'' positions: Improved antibacterial activities.
Bioorganic & Medicinal Chemistry(2010)
Abstract
The design and synthesis of 16-membered azalides modified at the C-15 and 4″ positions are described. 3-Hydroxyl azalides having an arylpropenyl and an ethylcarbamoyl group at the C-15 and C-4″ position, respectively, exhibited significant improvement in antibacterial activities against erm-resistant Streptococcus pneumoniae.
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Key words
16-Membered macrolide,Azalide,Acyl migration,S. pneumoniae,Antibacterial activity
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