Composite Pheochromocytoma Associated With Adrenal Neuroblastoma In An Infant: A Case Report

5-year-old boy presented with headache and hypertension. Screening abdominal ultrasonography showed a 6-cm-sized mass in the left adrenal gland. Laboratory data included urine vanillylmandelic acid/creatinine (208.3 mu g/mg), urine homovanillic acid/creatinine (114.3 pg/mg), serum epinephrine (237 pg/mL), and serum norepirlephrine (1842 pg/mL). Metaiodobenzyl guanidine I 123 scintigram, abdominal computed tomography, and abdominal magnetic resonance imaging revealed only left adrenal tumor with no inetastasis. Left adrenalectomy was performed transperitoneally, and histopathological diagnosis was in adrenal composite pheochromocytoma associated with neuroblastoma. Immunoreactivity for vimentin was positive in pheochromocytoma, which was negative in neuroblastoma. After operation, the symptom of hypertension disappeared. We should examine the identification of composite pheochromocytoma by immunohistochemistry method in patients with neuroblastomatous elements complicated by severe hypertension, and it is important to carefully monitor urine vanillylmandelic acid and urine homovanillic acid ill the examination tests and hypertension in the clinical symptoms, and follow Lip this patient because of some risk of recurrence and metastasis. (c) 2006 Elsevier Inc. All rights reserved.