[Haplotypes of DXS10011 and DXS8377 in Guangdong Han individuals].

OBJECTIVE:To investigate genetic polymorphism of two X chromosome specific STR: DXS10011 and DXS8377 in male samples from Guangdong Han population. METHODS:The DNA samples were amplified by PCR and analyzed by polyacrylamide gel electrophoresis followed by silver staining. RESULTS:Among 113 samples, 20 alleles were found for DXS1011 and 12 alleles for DXS8377. Also, 72 DXS10011-DXS8377 haplotypes were shown. The most common haplotypes only occurred three times. When only female children were tested in motherless case, the exclusion probability of paternity was 0.9588 for DXS10011-DXS8377 haplotypes. Investigations in 83 family trios with female children and 29 pedigrees with two children suggested a co-dominant X-linked inheritance; mutations were not found. CONCLUSION:Our data indicate that DXS10011 and DXS8377 are highly informative X chromosome markers for complicated kinship analysis.