Comparative Antiulcer And Antisecretory Effects Of Various Calcium-Antagonists

1.1. The antiulcer activity (ethanol or indomethacin-induced ulcers) and the antisecretory effects (pylorus-ligated rats) of various selective and non selective calcium antagonists were studied.2.2. Flunarizine and pirenzepine reduce the ethanol-ulcer length whereas diltiazem and cimetidine are weakly active and verapamil, nifedipine and nicardipine are ineffective.3.3. All tested compounds except verapamil prevent the development of indomethacin-induced ulceration.4.4. All substances, except flunarizine decrease the total H+ output in Shay rats.5.5. The activities of the different compounds are discussed in terms of their mode of action.