Detection of ESBLs-and AmpC-producing Klebsiella pneumoniaecausing nosocomial infections in eldely hospitalized patients and analysis of drug resistance

OBJECTIVE To understand the status of ESBLs-and AmpC-producing Klebsiella pneumoniae causing nosocomial infections in the elderly hospitalized patients so as to guide the clinical medication.METHODS The case-control study was conducted for the elderly hospitalized patients in 2011,and the ESBLs-and AmpC-producing K.pneumoniae isolated from various clinical specimens were collected,then the detection rate and the drug resistance were analyzed.RESULTS There were totally 97 strains of K.pneumoniae isolated from various specimens obtained from the elderly hospitalized patients,among which there were 29(29.9%) strains of ESBLs-producing isolates and 16(16.5%) strains of AmpC-producing isolates,and there were 8(8.3%)strains of ESBLs-and AmpC-producing isolates.The drug susceptibility testing result indicated that the enzyme-producing and non-anzyme-producing strains were 100% sensitive to imipenem and were highly resistant to the rest of the beta-lactam antibacterials cephalosporins,the drug resistance rate of the enzyme-producing strains was higher than that of the non-enzyme-producing strains,and the drug resistance rate of the ESBLs-and AmpC-producing stains was higher than that of the ESBLs-producing or AmpC-producing strains.CONCLUSION The detection rates of the ESBLs-producing K.pneumoniae and the AmpC-producing K.pneumoniae as well as the ESBLs-and AmpC-producing strains are high,and the enzyme-producing strains are multidrug-resistant.