2.01: Quarter-time myocardial perfusion SPECT wide beam reconstruction

Background: Compared to filtered backprojection (FBP) and iterative reconstruction with OSEM, wide beam reconstruction (WBR), which incorporates resolution recovery and models noise during reconstruction without applying a post-processing filter, has been reported to allow half- time gated myocardial perfusion SPECT acquisition with preserved diagnostic quality. We postulated that with further noise modeling even shorter acquisition times would be possible. Methods: The half-time WBR algorithm was modified for "quarter-time" acquisitions based upon anthropomorphic cardiac phantom data and a pilot group of 48 patients (pts). Pilot pts underwent 180-degree, 64-stop, full-time single-day rest (R) (25 second-per-stop (sps)) and stress (S) (20sps), and then "quarter-time" either R (6sps) (n=27 pts) or S (4 sps) (n=21pts) 9 mCi/32 mCi