Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor

Hayamitsu Adachi,Ken-Ichiro Kondo,Fukiko Kojima,Yoji Umezawa,Keiko Ishino,Hotta Kunimoto,Yoshio Nishimura,Yuzuru Akamatsu

LETTERS IN DRUG DESIGN & DISCOVERY（2008）

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摘要

8-Amino-2,8-dideoxy-beta-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- beta-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.

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关键词

gram-negative bacteria,lipopolysaccharide (LPS),CMP-KDO synthetase inhibitor

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