Synthesis of Octameric Phosphodiesters of[3,3-Bis(hydroxymethyl)cyclobutyl]adenine and -Thymine as well as their Hybridization Properties

The concept of antisense nucleic acids promises the possibility of specific interventions in the nucleic acid metabolism. Apart from the direct derivatives of ribose and deoxyribose, no structures that pair with RNA in the form of oligomeric phosphodiesters are known so far, The first examples, obtained from the carbanucleoside 1, namely octanucleotides of the type 2 (B = thymine, adenine), are reported here.