ChemInform Abstract: Regioselective Biomimetic Oxidation of Etodolac with Iodosylbenzene Catalyzed by Halogenated and Perhalogenated Metalloporphyrins in Dichloromethane.
Cheminform(2010)
Abstract
The biomimetic oxidation of etodolac, an anti-inflammatory drug (1) with iodosylbenzene catalyzed by 5,10,15,20-tetraaryl-porphyrinatoiron(III) chlorides TAPFe(III)Cl (7a—e) in dichloromethane gives 4-hydroxyetodolac (6) and 4-oxoetodolac (5) regioselectively in moderate yields.
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Key words
perhalogenated metalloporphyrins,regioselective biomimetic oxidation,iodosylbenzene catalyzed,dichloromethane
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