Change and relative analysis of serum levels of insulin-like growth factor-1and bone metabolization indexes in idiopathic short stature children

【Objective】 To mensure serum levels of insulin-like growth factor-1 and bone metabolization indexes,and to investigate the correlations between serum levels of insulin-like growth factor-1(IGF-1) and bone metabolization indexes,BA/CA,HtsDs in the children of idiopathic short stature(ISS). 【Methods】 Serum IGF-1,osteocalcin(OC),carboxyterminal propeptide of typeⅠprocollagen(PICP),type I collagen cross-linked C-terminal telopeptide(ICTP) were mensurated in 27 cases in ISS children,and compared to 30 cases age-and sex-matched healthy controls.The relationship between IGF-1,OC,PICP,ICTP,BA/CA and HtsDs were analyzed with Pearson correlation analysis. 【Results】 Compared with the normal group,The serum levels of IGF-1,OC,PICP,ICTP in ISS group were significantly decreased(P0.05).IGF-1 was positively correlated with OC,PICP,ICTP,BA/CA and HtsDs(P0.05). 【Conclusions】 Compared with the normal group,the level of bone turnover markers are significantly lower in ISS children.The lower serum level of insulin-like growth factor-1 might is significantly related to the changes of bone turnover markers and bone morphology.To guard against osteoporosis and ISS should be intervened.