A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters

Pavel Zhichkin,David J. Fairfax,Shane A. Eisenbeis

SYNTHESIS-STUTTGART（2002）

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摘要

A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.

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关键词

heterocycles,pyrimidines,condensation,amidinium salt,esters

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