A modified benzhydrylamine as a handle reagent for the solid phase synthesis of peptide amides based on the fluorenylmethoxycarbonyl method
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS(1988)
摘要
An easily preparable dimethoxybenzhydrylamine derivative, 3-(α-Fmoc-amino-4-methoxybenzyl)-4-methoxyphenyl propionic acid (Fmoc = fluoren-9-ylmethoxycarbonyl) is a useful precursor of the C-terminal amide, when applied to Fmoc-based solid phase peptide synthesis; as a cleavage reagent from the resin, thioanisole-mediated trimethylsilyl bromide in trifluoroacetic acid is recommended.
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关键词
Amide Bond Formation
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