苦参素联合钙离子拮抗剂治疗肝炎肝硬化疗效观察
Acta Academiae Medicinae Weifang(2008)
Abstract
目的观察苦参素联合钙离子拮抗剂治疗慢性乙肝后肝硬化对肝功能、肝脏血流动力学参数、血清肝纤维化指标等的影响。方法选择慢性乙肝肝硬化患者96例,Child-Pugh分级均为B级。随机分为治疗组56例和对照组40例。两组均给予苦参素(天晴复欣)600mg静脉滴注,1次/d(3个月)。治疗组在此基础上加用硝苯地平缓释片(伲福达)20mg/d,口服,2次/d(3个月)。比较两组患者的肝功能指标及血清肝纤维化指标并行肝脏B超测定肝门静脉血流动力学参数。结果3个月疗程结束后,治疗组上述指标明显改善。结论苦参素联合硝苯地平缓释片治疗慢性肝炎肝硬化在保肝、抗肝脏纤维化、降低门脉高压方面比单用苦参素效果理想。
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Key words
Liver function makers,Oxymatrine,Liver fibrosis,Hepatitis B,Liver cirrhosis after hepatitis,Nifedipine sustained release tablets
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