人脐带间充质干细胞移植减缓大鼠局灶性节段性肾小球硬化的进展
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology(2013)
Abstract
目的探讨人脐带间充质干细胞移植对局灶性节段性肾小球硬化(FSGS)进展的保护作用。方法贴壁法培养人脐带间充质干细胞,SD大鼠随机分为3组:对照组为正常SD大鼠,无任何干预措施;模型组及移植组大鼠分别在第1天、第8天尾静脉注射4 mg/kg、3.5 mg/kg阿霉素;移植组大鼠在第1、8、15、22天尾静脉注射HuMSCs细胞悬液(2×106个),而模型组尾静脉注射等剂量的DMEM 1 mL。结果人脐带间充质干细胞移植后能改善阿霉素肾病的尿蛋白及低白蛋白血症、降低血胱抑素C及改善肾脏病理损伤及肾间质炎性细胞浸润,肾组织TGF-β1和结缔组织生长因子(CTGF)表达降低,且血清中IL-6及TNF-α水平明显下降。结论人脐带间充质干细胞移植可减慢或阻止大鼠FSGS的进程。机制可能与调节炎性介质的合成、释放和抑制炎性细胞的浸润有关。
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Key words
human umbilical cord mesenchymal stem cell,connective tissue growth factor,cystatin c,focal segmental glomerulosclerosis,tgf-β1
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