117 SEROMARKERS FOR LONG-TERM PREDICTION OF HEPATOCELLULAR CARCINOMA RISK IN PATIENTS WITH CHRONIC HEPATITIS C

PRESENTATIONS(p = 0.05) score: ≤3 = 0, or ≥4 = 2. Two prognostic groups were identified in the TC according to score values ≤2 or ≥3, with 5-yr risk of recurrence of 16.7±2.6%and 47.5±4.7%,respectively (p < 0.0001).The model was validated in the 2 validation cohorts with, in particular, a 5-yr risk of recurrence of 9.0±1.7%(score ≤2) vs 47.3±9.5% (score ≥3), p < 0.001, in the ABM VC.In both cohorts, a score ≤2 was associated with better 5-yr overall survival: RVC: 80.6±3.5% vs 66.7±10.3%(p = 0.06) and ABM VC: 67.7±3.4% vs 49.1±7.4% (p = 0.002).In patients with score ≤2, recurrence and survival were similar whether patients met or not Milan criteria. Conclusions:1. AFP level is highly predictive of HCC recurrence after LT. 2. A prognostic score including AFP significantly improves the identification of patients with expanded criteria at low risk of recurrence.3. A score ≤2 could be proposed for selection of these patients.