Impact of early tumor shrinkage and depth of response on the outcomes of panitumumab-based maintenance in patients with RAS wild-type metastatic colorectal cancer

European Journal of Cancer（2021）

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摘要

•In Valentino trial, early tumor shrinkage/depth of response (ETS/DoR) is prognostic.•Poorest outcomes seen if no ETS/poor DoR + single-agent panitumumab maintenance.•Poorest outcomes seen if no ETS/poor DoR + resistance alterations beyond RAS/BRAF.•Tumor dynamics may be integrated in clinical trials or clinical decision-making.

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关键词

Metastatic colorectal cancer,Early tumor shrinkage,Depth of response,Maintenance therapy,Panitumumab,RAS wild-type,Molecular hyper-selection

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