2-aminomethylphenylamine as a novel scaffold for factor Xa inhibitor.
Bioorganic & Medicinal Chemistry(2011)
Abstract
We have been researching orally active factor Xa inhibitor for a long time. We explored the new diamine linker using effective ligands to obtain a new attractive original scaffold 2-aminomethylphenylamine derivative. Compound 1D showed very strong in vitro and in vivo factor Xa inhibitory activity, as well as favorable PK profiles in po administration to monkeys.
MoreTranslated text
Key words
LMUFNFLXBDOGET-UHFFFAOYSA-N
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined